Published: 06 Jun 2022 825 views
The assembly of membraneless organelles is emerging as a fundamental paradigm for many cellular functions. Among these, stress granules (SGs) play a central role in health and disease by concentrating proteins and RNAs, driving adaption to stressful conditions, including viral infection. SGs can be either cytoprotective or pro-death, anti-viral or pro-viral. SGs are proposed to act as part of larger coordinated waves of biocondensates assembly in the nucleus – paraspeckles which impact on splicing, and interact with cytoplasmic P-bodies involved in RNA decay. Despite this, the role of biocondensates in infection remains poorly understood. Because SGs and paraspeckles can have anti-viral functions, or promote replication, viruses provide a unique model to elucidate biocondensate functions. At Surrey, Professor Locker has already made fundamental advances in understanding SG function. With its nuclear replication and Professor West’s work at Sussex showing it repurposes cellular RNA binding proteins to regulate gene expression, Epstein-Barr Virus (EBV) provides an excellent to dissect the role of biocondensates during viral infection.
The University of Surrey was established on 9 September 1966 with the grant of its Royal Charter, but its roots go back to a late 19th-century concern to provide greater access to further and higher education for the poorer inhabitants of London. Since the University's founding in the 1960s, and before that at Battersea College, our community has thrived through strong connections and collaboration with the outside world. We've formed close partnerships with other institutions and businesses, reaching across geographic boundaries, and used those relationships to bring potential to life.... continue reading
Application Deadline | 20 Jun 2022 |
Country to study | United Kingdom |
School to study | University of Surrey |
Type | PhD |
Sponsor | University of Surrey |
Gender | Men and Women |
The PhD candidates selected by the University of Surrey will be provided with the following benefits:
Applications should be submitted via the Biosciences and Medicine PhD programme page on the "Apply" tab. Please clearly state the studentship title and supervisor on your application.